Sr9009 for Muscle Building Hormone Safe and Healthy
|FOB Price:||US $1-10 / grams|
|Min. Order:||1 grams|
|Min. Order||FOB Price|
|1 grams||US $1-10/ grams|
|Port:||Hong Kong, Hong Kong|
|Payment Terms:||T/T, Western Union, Paypal, Money Gram, Bitcoin|
- Model NO.: 98
- Certification: GMP, ISO 9001, USP, BP
- State: White Powder
- CAS Registry Number: 1379686-30-2
- Molecular Formula: C20h24cin3o4s
- Appearance: White or White-off Crystalline Powder
- Solubility: DMSO
- Trademark: moli
- Specification: 99
- HS Code: 3001200020
- Powder: Yes
- Suitable for: Adult
- Purity: >98%
- Assays: 98%Min by Lcms
- Molecular Weight: 437.94
- Packing: 1kg/Foil Bag
- Other Name: Sr9009
- Transport Package: Foil Bag
- Origin: China
1.Basic Information of SR9009
Pirity:98%min by LCMS
SR9009 also known as Stenabolic is a research drug that was developed by Professor Thomas Burris of the Scripps Research Institute as an agonist of Rev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA) with a half-maximum inhibitory concentration (IC50) = 670 nM for Rev-ErbAα and IC50 = 800 nM for Rev-ErbAβ.
Activation of Rev-erb-α by in mice SR9009 increases exercise capacity in mice by increasing mitochondria in skeletal muscle.
SR9009 is an agonist of REV-ERB with IC50 = 670 nM for REV-ERBα and IC50 = 800 nM for REV-ERBβ.
IC50 value: 670 nM (Rev-ErbBα), 800 nM (Rev-ErbBβ)
in vitro: SR9009 dose-dependently increases the REV-ERB-dependent repressor activity assessed in HEK293 cells expressing a chimeric Gal4 DNA Binding Domain (DBD) - REV-ERB ligand binding domain (LBD) α or β and a Gal4-responsive luciferase reporter. SR9009 potently and efficaciously suppresses transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9009 IC50=710 nM). SR9009 suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.
in vivo: SR9009 are synthetic REV-ERB agonists with activity. SR9009 also inhibits the activity of the SCN clock, with reversible inhibition of circadian oscillations in SCN explants cultured from the Per2:luc reporter mouse.
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